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Article

Low extracellular pH stimulates the production of IL-1β by human monocytes.

Cytokine - 1 Feb 2012

Jancic Carolina Cristina, Cabrini Mercedes, Gabelloni María Laura, Rodríguez Rodrigues Christian, Salamone Gabriela, Trevani Analía Silvina, Geffner Jorge

Abstract excerpt

The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that extracellular acidosis (pH 6.5) selectively stimulates the production and the secretion of IL-1β...

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Identifiers

PMID: 22154780
DOI: 10.1016/j.cyto.2011.11.013

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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