Article
Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels.
American journal of physiology. Cell physiology - 1 Nov 2000
Xu H, Yang Z, Cui N, Giwa L R, Abdulkadir L, Patel M, Sharma P, Shan G, Shen W, Jiang C
Abstract excerpt
Kir1.1 (ROMK1) is inhibited by hypercapnia and intracellular acidosis with midpoint pH for channel inhibition (pK(a)) of approximately 6.7. Another close relative, Kir4.1 (BIR10), is also pH sensitive with much lower pH sensitivity (pK(a) approximately 6. 0), although it shares a high sequence homology with Kir1.1. To find the molecular determinants for the distinct pH sensitivity, we studied the...
Topics
- Amino Acid Sequence
- Animals
- Carbon Dioxide
- Histidine
- Hydrogen-Ion Concentration
- Molecular Sequence Data
- Mutation
- Oocytes
- Potassium Channel Blockers
- Potassium Channels
- Potassium Channels, Inwardly Rectifying