KCC2-dependent Steady-state Intracellular Chloride Concentration and pH in Cortical Layer 2/3 Neurons of Anesthetized and Awake Mice

Abstract excerpt

Neuronal intracellular Cl - concentration ([Cl - ] i ) influences a wide range of processes such as neuronal inhibition, membrane potential dynamics, intracellular pH (pH i ) or cell volume. Up to date, neuronal [Cl - ] i has predominantly been studied in model systems of reduced complexity. Here, we implemented the genetically encoded ratiometric Cl - indicator Superclomeleon (SCLM) to estimate the steady-...

Topics

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• Action Potentials
• Carbon Dioxide
• Gills
• HEK293 Cells
• Hydrogen-Ion Concentration
• Potassium Channels, Tandem Pore Domain
• Zebrafish
• Zebrafish Proteins

Identifiers and source

Literature Corpus work

b40748d5-c877-565b-92ff-66586e86e729

DOI

10.1101/234476