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iClima: a ratiometric genetically encoded sensor for optical imaging of fast GABAergic chloride currents <i>in vitro</i> and <i>in vivo</i>

2026-05-29

Abstract excerpt

Fast GABAergic inhibition in the brain is mediated by chloride currents whose driving force depends on intracellular Cl − concentration ([Cl − ] i ). Resolving the spatiotemporal dynamics of [Cl − ] i in neurons requires a sensor combining high Cl − affinity, pH robustness, and photostability - properties no existing tool achieves simultaneously. Here we introduce iClima (improved Chloride Imaging), a ratiom...

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Literature Corpus work
e3f4b078-98f7-5a0c-a548-cbd874adef07
DOI
10.64898/2026.05.27.728254
Open publication

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iClima: a ratiometric genetically encoded sensor for optical imaging of fast GABAergic chloride currents <i>in vitro</i> and <i>in vivo</i>DOI 10.64898/2026.05.27.728254
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