Article
Bicarbonate-dependent proton extrusion in Chinese hamster ovary (CHO) cells adapted to growth at pH 6.7.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group - 1 Jan 2000
Coss R A, Messinger J A, Wahl M L, Wachsberger P R, Leeper D B, Owen C S
Abstract excerpt
A CHO cell model is described for in vitro studies of the mechanisms underlying heat resistance in cells adapted to growth in acidic environments. Adaptation is defined as a loss of pH 6.7-induced sensitization to 42.0 degrees C cytotoxicity and it is accompanied with an elevation of steady-state...
Topics
- Adaptation, Physiological
- Amiloride
- Animals
- Bicarbonates
- CHO Cells
- Cell Division
- Cricetinae
- Hot Temperature
- Hydrogen-Ion Concentration
- Kinetics
- Phenotype
- Protons