Article
Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.
Blood - 2 Feb 2017
Jain Nitin, Roberts Kathryn G, Jabbour Elias, Patel Keyur, Eterovic Agda Karina, Chen Ken, Zweidler-McKay Patrick, Lu Xinyan, Fawcett Gloria, Wang Sa A, Konoplev Sergej, Harvey Richard C, Chen I-Ming, Payne-Turner Debbie, Valentine Marcus, Thomas Deborah, Garcia-Manero Guillermo, Ravandi Farhad, Cortes Jorge, Kornblau Steven, O'Brien Susan, Pierce Sherry, Jorgensen Jeffrey, Shaw Kenna R Mills, Willman Cheryl L, Mullighan Charles G, Kantarjian Hagop, Konopleva Marina
Abstract excerpt
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults. Patients with newly diagnosed B-cell ALL (B-ALL) who received frontline chemotherapy at MD Anderson Cancer Center underwent gene expression profiling of leukemic cells. Of 148 patients, 33.1% had Ph-like, 31.1% had Ph+,...
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