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Article

Has Ph-like ALL Superseded Ph+ ALL as the Least Favorable Subtype?

Best practice & research. Clinical haematology - 1 Dec 2021

Tran Thai Hoa, Tasian Sarah K

Abstract excerpt

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a subset of high-risk B-ALL associated with high relapse risk and inferior clinical outcomes across the pediatric-to-adult age spectrum. Ph-like ALL is characterized by frequent IKZF1 alterations and a kinase-activated gene expression profile similar to that of Philadelphia chromosome-positive (Ph+) ALL, yet lacks the canonical BCR-ABL1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34865703
DOI: 10.1016/j.beha.2021.101331
PMCID: PMC8649641

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