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The Current Genomic and Molecular Landscape of Philadelphia-like Acute Lymphoblastic Leukemia

22 Mar 2020

Abstract excerpt

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk B-cell Acute Lymphoblastic Leukemia (B-ALL) characterized by a gene expression profile similar to Ph-positive B-ALL but lacking the BCR-ABL1 translocation. The molecular pathogenesis of Ph-like B-ALL is heterogenous and involves aberrant genomics, receptor overexpression, kinase fusions, and mutations leading to kinase signaling activation,...

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PMID: 32235787
DOI: 10.3390/ijms21062193

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