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Advances in the Genetics and Therapy of Acute Lymphoblastic Leukemia

1 Jan 2016

Abstract excerpt

Acute lymphoblastic leukemia (ALL) remains an important cause of morbidity in children and adults. In this article, we highlight advances in the genetics and therapy of three key subtypes of ALL: T-cell ALL, BCR-ABL1 (Philadelphia [Ph] chromosone-positive), and Ph-like ALL. T-ALL is an aggressive disease that accounts for about 15% and 25% of ALL among pediatric and adult cohorts, respectively, and exhibits a...

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PMID: 27249738
DOI: 10.14694/edbk_156628

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