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Article

Coding and Noncoding Variants in CFH Act Synergistically for Complement Activation in Immunoglobulin A Nephropathy.

The American journal of the medical sciences - 1 Aug 2018

Guo Wei-Yi, Liu Qing-Zhen, Zhu Li, Li Zeng-Yan, Meng Si-Jun, Shi Su-Fang, Liu Li-Jun, Lv Ji-Cheng, Hou Ping, Zhang Hong

Abstract excerpt

BACKGROUND: In immunoglobulin A nephropathy (IgAN), complement activation occurs in both the systemic circulation and in situ (glomerular). A recent IgAN-genome-wide association study (GWAS) identified 1q32 as an IgAN susceptible locus that contained the complement regulatory protein coding gene complement factor H (CFH). Here, we explored the combined genetic effects of coding and noncoding variants in CFH,...

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Share to Chromosomes, Human, Pair 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glomerulonephritis, IGA

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Identifiers

PMID: 30219152
DOI: 10.1016/j.amjms.2018.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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