Article
Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer’s disease
2017-11-08
Abstract excerpt
Alzheimer’s disease (AD) is a severe neurodegenerative disorder. Identification of differentially expressed genes in AD would help to find biomarker and therapeutic target. Here, we carried out an analysis to identify the age-independent and AD-specific genes. We found that genes MET, WIF1 and NPTX2 are down regulated in AD. WIF1 and MET are in signaling of WNT and MET, regulating the activity of GSK3β, thus in AD...
Topics
Open a Topic to create a Post that cites this publication.
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- GDF15 and Related Biomarkers
- Ginseng Biological Effects and Applications
- Histone Deacetylase Inhibitors Research
- Paraoxonase enzyme and polymorphisms
Identifiers and source
- Literature Corpus work
- 5f818d68-5da5-5328-b03f-671275ae7aa9
- DOI
- 10.1101/215947