Article
Genome-wide pathway analysis of memory impairment in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks.
Brain imaging and behavior - 1 Dec 2012
Ramanan Vijay K, Kim Sungeun, Holohan Kelly, Shen Li, Nho Kwangsik, Risacher Shannon L, Foroud Tatiana M, Mukherjee Shubhabrata, Crane Paul K, Aisen Paul S, Petersen Ronald C, Weiner Michael W, Saykin Andrew J
Abstract excerpt
Memory deficits are prominent features of mild cognitive impairment (MCI) and Alzheimer's disease (AD). The genetic architecture underlying these memory deficits likely involves the combined effects of multiple genetic variants operative within numerous biological pathways. In order to identify functional pathways associated with memory impairment, we performed a pathway enrichment analysis on genome-wide...
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