Article
Density-based separation in multiphase systems provides a simple method to identify sickle cell disease.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2014
Kumar Ashok A, Patton Matthew R, Hennek Jonathan W, Lee Si Yi Ryan, D'Alesio-Spina Gaetana, Yang Xiaoxi, Kanter Julie, Shevkoplyas Sergey S, Brugnara Carlo, Whitesides George M
Abstract excerpt
Although effective low-cost interventions exist, child mortality attributable to sickle cell disease (SCD) remains high in low-resource areas due, in large part, to the lack of accessible diagnostic methods. The presence of dense (ρ > 1.120 g/cm(3)) cells is characteristic of SCD. The fluid, self-assembling step-gradients in density created by aqueous multiphase systems (AMPSs) identifies SCD by detecting dense...
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