Article

Novel approach towards pathogenesis and treatment of sickle cell disease

2019-01-01

Abstract excerpt

Sickle cell disease (SCD) is one of the most common genetic diseases worldwide. HbS polymerisation causes altered red blood cell (RBC) rheology and fragility, increase in blood viscosity with blockage of small blood vessels, and RBC membrane permeability changes. Excessive levels of cell-free Hb, high autoxidation of Hb, contribute to the production of reactive oxygen species (ROS) in SCD patients. In this work, o...

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Literature Corpus work: f608c0f9-6de5-5107-8623-71d4e1f4cbad
DOI: 10.17863/cam.36000

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