Oxygen gradient ektacytometry‐derived biomarkers are associated with vaso‐occlusive crises and correlate with treatment response in sickle cell disease

Abstract excerpt

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single nucleotide mutation in the β-globin gene leading to the production of an abnormal hemoglobin S (HbS). When HbS becomes deoxygenated it polymerizes, deforming the red blood cells (RBCs) into a curved or sickle shape. Sickle RBCs are rigid and poorly deformable, and together with other abnormalities, block the microvasculature, causing...

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