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Differential sensitivity to hypoxia enables shape‐based classification of sickle cell disease and trait blood samples at point of care

27 Dec 2023

Abstract excerpt

Red blood cells (RBCs) become sickle-shaped and stiff under hypoxia as a consequence of hemoglobin (Hb) polymerization in sickle cell anemia. Distinguishing between sickle cell disease and trait is crucial during the diagnosis of sickle cell disease. While genetic analysis or high-performance liquid chromatography (HPLC) can accurately differentiate between these two genotypes, these tests are unsuitable for...

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PMID: 39036093
DOI: 10.1002/btm2.10643

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