Article

Microfluidic Microcirculation Mimetic as a Tool for the Study of Rheological Characteristics of Red Cells in Patients With Sickle Cell Anaemia

2022-02-25

Abstract excerpt

Sickle cell disorder (SCD) is a multisystem disease with heterogeneous phenotypes. Although all patients have the mutated haemoglobin (Hb) in the SS phenotype, the severity and frequency of complications are variable. When exposed to low oxygen tension, the Hb molecule becomes dense and, forms tactoids which, lead to the peculiar sickled shapes of the affected red blood cells, giving the disorder its name. This si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7d73e04-2c6a-5c54-a40b-81235017d569
DOI: 10.20944/preprints202202.0329.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microfluidic Microcirculation Mimetic as a Tool for the Study of Rheological Characteristics of Red Cells in Patients With Sickle Cell AnaemiaDOI 10.20944/preprints202202.0329.v1Read

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis.Semantic proximity Read

A novel red blood cell deformability biomarker is associated with hemolysis and vaso-occlusive crises in sickle cell diseaseSemantic proximity Read

Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments.Semantic proximity Read

Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.Semantic proximity Read

Assessing the Clinical Outcomes of Voxelotor Treatment in Patients with Sickle Cell DiseaseSemantic proximity Read

Suspension physics govern the multiscale dynamics of blood flow in sickle cell diseaseSemantic proximity Read

Blood rheology and vascular function in sickle cell trait and sickle cell disease: From pathophysiological mechanisms to clinical usefulnessSemantic proximity Read

Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease ComplicationsSemantic proximity Read

The role of blood rheology in sickle cell disease.Semantic proximity Read

Patient-specific modeling of individual sickle cell behavior under transient hypoxiaSemantic proximity Read

Integrated automated particle tracking microfluidic enables high‐throughput cell deformability cytometry for red cell disordersSemantic proximity Read

New Insights into Hemolytic Anemias: Ultrastructural and Nanomechanical Investigation of Red Blood Cells Showed Early Morphological ChangesSemantic proximity Read