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Article

Pathophysiological-Based Approaches to Treatment of Sickle Cell Disease

13 Jan 2003

Abstract excerpt

Sickle hemoglobin (HbS), as a result of its polymer-related and oxidant effects, damages the sickle erythrocyte, provokes inflammation, and causes endothelial injury. All these elements cause the phenotype of sickle cell disease. Novel treatments inhibit HbS polymerization by inducing fetal hemoglobin expression, prevent or repair erythrocyte dehydration by slowing cellular potassium and water loss, and replace...

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Share to Erythrocyte Function and Pathophysiology
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PMID: 12359829
DOI: 10.1146/annurev.med.54.101601.152439

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