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Article

Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart.

Journal of cardiovascular translational research - 1 Dec 2016

Levitan Bryana M, Manning Janet R, Withers Catherine N, Smith Jeffrey D, Shaw Robin M, Andres Douglas A, Sorrell Vincent L, Satin Jonathan

Abstract excerpt

Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad-/-) renders LTCC in a sympathomimetic state. The study goal was to use a clinically inspired pharmacological stress echocardiography test, including analysis of global strain, to determine whether Rad-/-...

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Identifiers

PMID: 27798760
DOI: 10.1007/s12265-016-9716-y
PMCID: PMC5143207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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