Article
Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.
The Journal of biological chemistry - 12 Oct 2007
Xiao Bailong, Tian Xixi, Xie Wenjun, Jones Peter P, Cai Shitian, Wang Xianhua, Jiang Dawei, Kong Huihui, Zhang Lin, Chen Keyun, Walsh Michael P, Cheng Heping, Chen S R Wayne
Abstract excerpt
The phosphorylation of the cardiac Ca(2+)-release channel (ryanodine receptor, RyR2) by protein kinase A (PKA) has been extensively characterized, but its functional consequence remains poorly defined and controversial. We have previously shown that RyR2 is phosphorylated by PKA at two major sites, serine 2,030 and serine 2,808, of which Ser-2,030 is the major PKA site responding to beta-adrenergic stimulation....
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