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Article

Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2010

Sarma Satyam, Li Na, van Oort Ralph J, Reynolds Corey, Skapura Darlene G, Wehrens Xander H T

Abstract excerpt

Aberrant intracellular Ca(2+) regulation is believed to contribute to the development of cardiomyopathy in Duchenne muscular dystrophy. Here, we tested whether inhibition of protein kinase A (PKA) phosphorylation of ryanodine receptor type 2 (RyR2) prevents dystrophic cardiomyopathy by reducing S...

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Identifiers

PMID: 20615971
DOI: 10.1073/pnas.1004509107
PMCID: PMC2919918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20615971-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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