Article

Direct monitoring of cAMP at the cardiac ryanodine receptor using a novel targeted fluorescence biosensor mouse

2019-04-30

Abstract excerpt

<h4>Rationale</h4> Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger which, upon β-adrenergic receptor (β-AR) stimulation, acts in microdomains to regulate cardiac excitation-contraction coupling by activating the cAMP-dependent protein kinase (PKA) phosphorylation of calcium handling proteins. One crucial microdomain is in vicinity of the cardiac ryanodine receptor type 2 (RyR2) which is ass...

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Literature Corpus work: 3130a782-e8f4-5934-bff0-8e82b4c41735
DOI: 10.1101/623934

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