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Article

Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.

Molecular cancer research : MCR - 1 Jan 2015

Sowalsky Adam G, Xia Zheng, Wang Liguo, Zhao Hao, Chen Shaoyong, Bubley Glenn J, Balk Steven P, Li Wei

Abstract excerpt

UNLABELLED: Men with metastatic prostate cancer who are treated with androgen deprivation therapies (ADT) usually relapse within 2 to 3 years with disease that is termed castration-resistant prostate cancer (CRPC). To identify the mechanism that drives these advanced tumors, paired-end RNA-sequencing (RNA-seq) was performed on a panel of CRPC bone marrow biopsy specimens. From this genome-wide approach, mutations...

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Topics

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Share to Gene Expression Regulation, Neoplastic
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasm Proteins

Share to Neoplasm Recurrence, Local

Share to Prostatic Neoplasms, Castration-Resistant

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Source

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Identifiers

PMID: 25189356
DOI: 10.1158/1541-7786.MCR-14-0273
PMCID: PMC4312515

Genes

BRAF
CDH1
CDK19
CHD1
CPSF6
KLK2
KLK3
NCOR1
PABPC1
RASA1
RASGRP3
SETD5
SETD7
SND1
STEAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.PMID 25189356Read ↗

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The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate CancerSemantic proximity Read ↗

Identification of long non-coding RNAs in advanced prostate cancer associated with androgen receptor splicing factorsSemantic proximity Read ↗

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RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings.Semantic proximity Read ↗

LNCaP Atlas: Gene expression associated with in vivoprogression to castration-recurrent prostate cancerSemantic proximity Read ↗

Transcriptomic analysis of castration, chemo-resistant and metastatic prostate cancer elucidates complex genetic crosstalk leading to disease progressionSemantic proximity Read ↗

Single cell-transcriptomic analysis informs the lncRNA landscape in metastatic castration resistant prostate cancerSemantic proximity Read ↗

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