Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model.

Cancer letters - 1 Jan 2014

Wang Yongqing, Wang Yan, Liu Qi, Xu Gang, Mao Fengbiao, Qin Tingting, Teng Huajing, Cai Wanshi, Yu Ping, Cai Tao, Zhao Mei, Sun Zhong Sheng, Xie Congying

Abstract excerpt

The androgen-independent phenotype is an important symptom of refractory prostate cancer. However, the molecular mechanisms underlying this phenotypic conversion remain unclear. Using RNA-seq analysis of androgen-dependent prostate cancer cells (LNCaP) vs. androgen-independent cancer cells (LNCaP-AI-F), we identified 788 differentially expressed genes, 315 alternative splicing events, and eight novel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Fusion

Share to Gene Regulatory Networks

Share to Prostatic Neoplasms, Castration-Resistant

Share to Sequence Analysis, RNA

Share to Transcriptome

Source

Identifiers

PMID: 24012641
DOI: 10.1016/j.canlet.2013.08.044

Genes

ATR
GLYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model.PMID 24012641Read ↗

Alternative splicing in prostate cancer progression and therapeutic resistanceSemantic proximity Read ↗

Androgen receptor signaling regulates the transcriptome of prostate cancer cells by modulating global alternative splicingSemantic proximity Read ↗

Androgen Receptor Signaling Regulates the Transcriptome of Prostate Cancer Cells by Modulating Global Alternative SplicingSemantic proximity Read ↗

Unravelling the molecular mechanisms of prostate cancer evolution from genotype to phenotype.Semantic proximity Read ↗

LNCaP Atlas: Gene expression associated with in vivoprogression to castration-recurrent prostate cancerSemantic proximity Read ↗

Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independenceSemantic proximity Read ↗

Single-cell sequencing analysis revealed that NEAT1 was a potential biomarker and therapeutic target of prostate cancerSemantic proximity Read ↗

Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axesSemantic proximity Read ↗

Mechanisms of resistance to androgen deprivation therapy in prostate cancer.Semantic proximity Read ↗

Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiationSemantic proximity Read ↗

RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings.Semantic proximity Read ↗

Androgen-dependent alternative mRNA isoform expression in prostate cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.