Article
Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2011
Kumar Akash, White Thomas A, MacKenzie Alexandra P, Clegg Nigel, Lee Choli, Dumpit Ruth F, Coleman Ilsa, Ng Sarah B, Salipante Stephen J, Rieder Mark J, Nickerson Deborah A, Corey Eva, Lange Paul H, Morrissey Colm, Vessella Robert L, Nelson Peter S, Shendure Jay
Abstract excerpt
To catalog protein-altering mutations that may drive the development of prostate cancers and their progression to metastatic disease systematically, we performed whole-exome sequencing of 23 prostate cancers derived from 16 different lethal metastatic tumors and three high-grade primary carcinomas. All tumors were propagated in mice as xenografts, designated the LuCaP series, to model phenotypic variation, such...
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