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The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer

8 Jun 2023

Abstract excerpt

Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)-targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC), defined by AR and neuroendocrine (NE) markers. Molecular drivers of double-negative (AR-/NE-) mCRPC...

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PMID: 37289025
DOI: 10.1158/0008-5472.can-23-0593

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