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Article

The mutational landscape of lethal castration-resistant prostate cancer.

Nature - 12 Jul 2012

Grasso Catherine S, Wu Yi-Mi, Robinson Dan R, Cao Xuhong, Dhanasekaran Saravana M, Khan Amjad P, Quist Michael J, Jing Xiaojun, Lonigro Robert J, Brenner J Chad, Asangani Irfan A, Ateeq Bushra, Chun Sang Y, Siddiqui Javed, Sam Lee, Anstett Matt, Mehra Rohit, Prensner John R, Palanisamy Nallasivam, Ryslik Gregory A, Vandin Fabio, Raphael Benjamin J, Kunju Lakshmi P, Rhodes Daniel R, Pienta Kenneth J, Chinnaiyan Arul M, Tomlins Scott A

Abstract excerpt

Characterization of the prostate cancer transcriptome and genome has identified chromosomal rearrangements and copy number gains and losses, including ETS gene family fusions, PTEN loss and androgen receptor (AR) amplification, which drive prostate cancer development and progression to lethal, metastatic castration-resistant prostate cancer (CRPC). However, less is known about the role of mutations. Here we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22722839
DOI: 10.1038/nature11125
PMCID: PMC3396711

Genes

FOXA1
ERG
ASXL1
CHD1
ETS2
PTEN
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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