Article
Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2011
Burns L C, Minster R L, Demirci F Y, Barmada M M, Ganguli M, Lopez O L, DeKosky S T, Kamboh M I
Abstract excerpt
Late-onset Alzheimer's disease (LOAD) is a multifactorial disease with the potential involvement of multiple genes. Four recent genome-wide association studies (GWAS) have found variants showing significant association with LOAD on chromosomes 6, 10, 11, 12, 14, 18, 19, and on the X chromosome. We examined a total of 12 significant SNPs from these studies to determine if the results could be replicated in an...
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