Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives.

Gene - 15 Jan 2017

Dong Hee Kim, Gim Jeong-An, Yeo Seung Hyeon, Kim Heui-Soo

Abstract excerpt

Late onset Alzheimer's disease (LOAD) is the most common type of dementia and is characterized by decreased amyloid-β (Aβ) clearance from the brain. Cholesterol regulates the production and clearance of Aβ. Genome-wide association study (GWAS) suggests that at least 20 genes are associated with LOAD. The genes APOE, CLU, SORL1, PICALM, and BIN1 have a relatively high LOAD susceptibility. Additional experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Biological Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol

Share to Clusterin

Share to Epistasis, Genetic

Share to LDL-Receptor Related Proteins

Share to Monomeric Clathrin Assembly Proteins

Share to Protein Interaction Mapping

Source

Identifiers

PMID: 27773727
DOI: 10.1016/j.gene.2016.10.022

Genes

APOE
BIN1
CLU
PICALM
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives.PMID 27773727Read ↗

Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated PathwaysSemantic proximity Read ↗

Impact of late-onset Alzheimer's genetic risk factors on beta-amyloid endocytic production.Semantic proximity Read ↗

New genetic players in late-onset Alzheimer's diseaseSemantic proximity Read ↗

Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease.Semantic proximity Read ↗

The three new pathways leading to Alzheimer's disease.Semantic proximity Read ↗

Genetics of Late‐Onset Alzheimer′s Disease: Update from the Alzgene Database and Analysis of Shared PathwaysSemantic proximity Read ↗

Genetics of Alzheimer's disease.Semantic proximity Read ↗

The Genetics of Alzheimer’s DiseaseSemantic proximity Read ↗

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.Semantic proximity Read ↗

Alzheimer's Disease Risk Genes and Lipid Regulators.Semantic proximity Read ↗

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.Semantic proximity Read ↗

Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.