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Article

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2024

Archer Derek B, Eissman Jaclyn M, Mukherjee Shubhabrata, Lee Michael L, Choi Seo-Eun, Scollard Phoebe, Trittschuh Emily H, Mez Jesse B, Bush William S, Kunkle Brian W, Naj Adam C, Gifford Katherine A, Cuccaro Michael L, Pericak-Vance Margaret A, Farrer Lindsay A, Wang Li-San, Schellenberg Gerard D, Mayeux Richard P, Haines Jonathan L, Jefferson Angela L, Kukull Walter A, Keene C Dirk, Saykin Andrew J, Thompson Paul M, Martin Eden R, Bennett David A, Barnes Lisa L, Schneider Julie A, Crane Paul K, Dumitrescu Logan, Hohman Timothy J

Abstract excerpt

INTRODUCTION: Although large-scale genome-wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline. METHODS: We conducted a cross-ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations) by leveraging harmonized cognitive data from four aging cohorts....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37985223
DOI: 10.1002/alz.13508
PMCID: PMC10896586

Genes

BSX
DPP8
SLC25A44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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