Article
Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development.
Genesis (New York, N.Y. : 2000) - 1 Apr 2007
Sevrioukov Evgueni A, Burr John, Huang Eric W, Assi Hikmat H, Monserrate Jessica P, Purves Dianne C, Wu Julie N, Song Eyun J, Brachmann Carrie Baker
Abstract excerpt
Many developing tissues require programmed cell death (PCD) for proper formation. In mice and C. elegans, developmental PCD is regulated by the Bcl-2 family of proteins. Two bcl-2 genes are encoded in the Drosophila genome (debcl/dBorg1/Drob-1/dBok and buffy/dBorg2) and previous RNAi-based studies suggested a requirement for these in embryonic development. However, we report here that, despite the fact that many...
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