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Article

Novel mutations and role of the LKB1 gene as a tumor suppressor in renal cell carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2014

Yalniz Zübeyde, Tigli Hulya, Tigli Hatice, Sanli Oner, Dalay Nejat, Buyru Nur

Abstract excerpt

The tumor suppressor LKB1 gene is a master kinase and inhibits mammalian target of rapamycin (mTOR) by activating AMP-activated protein kinase (AMPK) and AMPK-related kinases. LKB1 is a critical intermediate in the mTOR signaling pathway, and mutations of the LKB1 gene have been implicated in the development of different tumor types. Recent evidence indicates that LKB1 alterations contribute to cancer progression...

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Share to AMP-Activated Protein Kinase Kinases
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Kidney Neoplasms

Share to Neoplasm Grading

Share to Neoplasm Metastasis

Share to TOR Serine-Threonine Kinases

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Source

Identifiers

PMID: 25179843
DOI: 10.1007/s13277-014-2550-4

Genes

RHEB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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