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Article

Phe354Leu Polymorphism of LKB1 Is a Potential Prognostic Factor for Cytogenetically Normal Acute Myeloid Leukemia.

In vivo (Athens, Greece) - 1 Jan 2000

Yang Ming-Yu, Hsiao Hui-Hua, Liu Yi-Chang, Hsu Cheng-Ming, Lin Sheng-Fung, Lin Pai-Mei

Abstract excerpt

BACKGROUND/AIM: Liver kinase B1 (LKB1) is a major activator of the AMP-dependent kinase/mammalian target of rapamycin pathway. The prevalence and the specificity of LKB1 gene mutation in acute myeloid leukemia (AML) have not been well established. This study aimed to examine mutation of LKB1 in AML and its clinical and pathological implications. PATIENTS AND METHODS: Eighty-five patients newly diagnosed with...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytogenetic Analysis

Share to Leukemia, Myeloid, Acute

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Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 28882949
DOI: 10.21873/invivo.11137
PMCID: PMC5656856

Genes

FLT3
IDH1
IDH2
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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