Article
LKB1 mutations and their correlation with LKB1 and Rheb expression in bladder cancer.
Molecular carcinogenesis - 1 Aug 2013
Tigli Hatice, Seven Didem, Tunc Murat, Sanli Oner, Basaran Serife, Ulutin Turgut, Buyru Nur
Abstract excerpt
Although there are extensive studies on the genetics of bladder cancer, several questions remain unanswered. One of the pathways which are altered in bladder cancer is the mTOR signaling pathway. In the present study, we analyzed the expression of Rheb gene and genetic alterations in the LKB1 gene which are the key components of mTOR pathway. Nine exons of the LKB1 gene were analyzed by direct sequencing in 51...
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