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Article

Human endotoxin tolerance is associated with enrichment of the CD14+ CD16+ monocyte subset.

Immunobiology - 1 Jan 2015

Domínguez-Nieto Aimée, Zentella Alejandro, Moreno José, Ventura José L, Pedraza Sigifredo, Velázquez Juan R

Abstract excerpt

Prior exposure to lipopolysaccharides (LPS) induces a state of cell resistance to subsequent LPS restimulation, known as endotoxin tolerance, mainly by repressing the expression of pro-inflammatory cytokines. We established an endotoxin tolerance model in human monocytes Endotoxin-tolerant cells showed a decrease in IκBα degradation and diminished expression of Tumor necrosis factor (TNF) (both messenger RNA...

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Share to Chemokine CXCL10
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid Differentiation Factor 88

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Source

Identifiers

PMID: 25172544
DOI: 10.1016/j.imbio.2014.08.008

Genes

CXCL10
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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