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Article

Endotoxin tolerance induces selective alterations in neutrophil function.

Journal of leukocyte biology - 1 Dec 2005

Parker Lisa C, Jones Elizabeth C, Prince Lynne R, Dower Steven K, Whyte Moira K B, Sabroe Ian

Abstract excerpt

Endotoxin tolerance has the potential to limit phagocyte responses to Toll-like receptor (TLR) agonists, but the role of tolerance in regulating neutrophil responses is unknown. We investigated neutrophil responses to prolonged lipopolysaccharide (LPS) exposure and observed induction of tolerance in intracellular signaling pathways and respiratory burst. These effects were not prevented by granulocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16244113
DOI: 10.1189/jlb.0405236

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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