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Article

Maximal Exercise Alters the Inflammatory Phenotype and Response of Mononuclear Cells.

Medicine and science in sports and exercise - 1 Apr 2018

Slusher Aaron L, Zúñiga Tiffany M, Acevedo Edmund O

Abstract excerpt

PURPOSE: Monocytes express the CD14 receptor that facilitates lipopolysaccharide (LPS) ligation to toll-like receptor 4 (TLR4) to elicit production of interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNF-α). However, proinflammatory conditions, such as strenuous exercise, increase the percentage of monocytes expressing CD16, a receptor that enhances LPS stimulated TNF-α production. Therefore, we...

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Source

Identifiers

PMID: 29112629
DOI: 10.1249/MSS.0000000000001480

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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