Article

The Effect of Magnesium Sulfate on Lipopolysaccharide Tolerance in Human Monocytes

2022-01-24

Abstract excerpt

Binding of lipopolysaccharide (LPS) to toll-like receptor 4 induces release of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) and leads to inflammatory pathologies. An immunosuppression status develops together with LPS-induced inflammation named LPS tolerance, which refers to downregulation of LPS signaling after pre-exposure of LPS, providing protection against hyperactive inflammation. Dur...

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Literature Corpus work: c97c371f-8035-519c-a777-90fed96cf2c3
DOI: 10.21203/rs.3.rs-1246265/v1

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