Article
NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT.
Molecular genetics and metabolism - 1 Jan 2000
John Gerrit, Hegarty John P, Yu Wei, Berg Arthur, Pastor Danielle M, Kelly Ashley A, Wang Yunhua, Poritz Lisa S, Schreiber Stefan, Koltun Walter A, Lin Zhenwu
Abstract excerpt
NKX2-3 SNP rs11190140 is associated with inflammatory bowel disease (IBD). The T allele is over-transmitted in IBD and the C allele represents a potential CpG methylation site. We hypothesize that genetic variation and/or methylation of SNP rs11190140 may play a role in NKX2-3 gene expression by affecting transcription factor binding. We studied 233 IBD cases and 250 unrelated healthy individuals from an IBD...
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