Article
Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.
Inflammatory bowel diseases - 1 May 2012
Nimmo Elaine R, Prendergast James G, Aldhous Marian C, Kennedy Nicholas A, Henderson Paul, Drummond Hazel E, Ramsahoye Bernard H, Wilson David C, Semple Colin A, Satsangi Jack
Abstract excerpt
BACKGROUND: Germline variation in the 71 Crohn's disease (CD) loci implicated by genome-wide association studies (GWAS) only accounts for approximately 25% of estimated heritability. The contribution of epigenetic alterations to disease pathogenesis is emerging as a research priority. MATERIALS AND METHODS: The methylation status of 27,578 CpG sites across the genome was analyzed using the Illumina Human...
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