The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes.

doi:10.1073/pnas.2013500118

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Article

The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes.

Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2021

Ranjan Kishu, Hedl Matija, Abraham Clara

Abstract excerpt

Balancing microbial-induced cytokines and microbial clearance is critical at mucosal sites such as the intestine. How the inflammatory bowel disease (IBD)-associated gene RNF186 regulates this balance is unclear. We found that macrophages from IBD-risk rs6426833 carriers in the RNF186 region showed reduced cytokines to stimulation through multiple pattern recognition receptors (PRRs). Upon stimulation of PRRs,...

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Identifiers

PMID: 34353900
DOI: 10.1073/pnas.2013500118
PMCID: PMC8364215

Genes

RNF186

Variants

rs6426833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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