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Article

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.

PloS one - 1 Jan 2014

De Nicola Stella, Dongiovanni Paola, Aghemo Alessio, Cheroni Cristina, D'Ambrosio Roberta, Pedrazzini Michele, Marabita Francesco, Donnici Lorena, Maggioni Marco, Fargion Silvia, Colombo Massimo, De Francesco Raffaele, Valenti Luca

Abstract excerpt

BACKGROUND AND AIMS: The PNPLA3 I148M sequence variant favors hepatic lipid accumulation and confers susceptibility to hepatic fibrosis and hepatocellular carcinoma. The aim of this study was to estimate the effect size of homozygosity for the PNPLA3 I148M variant (148M/M) on the fibrosis progression rate (FPR) and the interaction with age at infection in chronic hepatitis C (CHC). METHODS: FPR was estimated in a...

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Source

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Identifiers

PMID: 25171251
DOI: 10.1371/journal.pone.0106022
PMCID: PMC4149487

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.PMID 25171251Read ↗

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