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Article

PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2014

Burza Maria Antonella, Molinaro Antonio, Attilia Maria Luisa, Rotondo Claudia, Attilia Fabio, Ceccanti Mauro, Ferri Flaminia, Maldarelli Federica, Maffongelli Angela, De Santis Adriano, Attili Adolfo Francesco, Romeo Stefano, Ginanni Corradini Stefano

Abstract excerpt

BACKGROUND & AIMS: Environmental and genetic factors contribute to alcoholic cirrhosis onset. In particular, age at exposure to liver stressors has been shown to be important in progression to fibrosis in hepatitis C individuals. However, no definite data on the role of age at onset of at-risk al...

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Source

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Identifiers

PMID: 24102786
DOI: 10.1111/liv.12310
PMCID: PMC4265268

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24102786-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis.PMID 24102786Read ↗

PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival.Semantic proximity Read ↗

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.Semantic proximity Read ↗

PNPLA3 I148M and Hepatocellular Carcinoma.Semantic proximity Read ↗

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis.Semantic proximity Read ↗

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.Semantic proximity Read ↗

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians.Semantic proximity Read ↗

Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis.Semantic proximity Read ↗

PNPLA3 polymorphisms and risk of hepatic and extrahepatic outcomes in MASLD: A meta-analysis of observational studies.Semantic proximity Read ↗

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.Semantic proximity Read ↗

Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis.Semantic proximity Read ↗

PNPLA3 I148M polymorphism and progressive liver disease.Semantic proximity Read ↗

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