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Article

PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma.

PloS one - 1 Jan 2013

Valenti Luca, Motta Benedetta Maria, Soardo Giorgio, Iavarone Massimo, Donati Benedetta, Sangiovanni Angelo, Carnelutti Alessia, Dongiovanni Paola, Rametta Raffaela, Bertelli Cristina, Facchetti Floriana, Colombo Massimo, Fargion Silvia, Fracanzani Anna Ludovica

Abstract excerpt

BACKGROUND & AIMS: Aim of this study was to evaluate whether the PNPLA3 I148M polymorphism, previously associated with hepatocellular carcinoma (HCC) risk, influences the clinical presentation of HCC and survival. METHODS: we considered 460 consecutive HCC patients referred to tertiary care centers in Northern Italy, 353 with follow-up data. RESULTS: Homozygosity for PNPLA3 148M at risk allele was enriched in HCC...

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Identifiers

PMID: 24155878
DOI: 10.1371/journal.pone.0075982
PMCID: PMC3796509

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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