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Article

Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin.

Alimentary pharmacology & therapeutics - 1 Jun 2012

Valenti L, Aghemo A, Stättermayer A F, Maggioni P, De Nicola S, Motta B M, Rumi M G, Dongiovanni P, Ferenci P, Colombo M, Fargion S

Abstract excerpt

BACKGROUND: Homozygosity for the PNPLA3 p.I148M polymorphism influences steatosis and fibrogenesis in chronic hepatitis C (CHC). AIM: To evaluate the effect of p.148M/M on sustained virological response (SVR) and viral kinetics in patients who underwent antiviral therapy with peg-interferon and ribavirin, stratified according to viral genotype and fibrosis severity, and secondarily, the interaction with...

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Source

Identifiers

PMID: 22530607
DOI: 10.1111/j.1365-2036.2012.05109.x

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin.PMID 22530607Read ↗

Association between PNPLA3[G]/I148M variant, steatosis and fibrosis stage in hepatitis C virus - genetic matters.Semantic proximity Read ↗

PNPLA3 rs738409 causes steatosis according to viral & IL28B genotypes in hepatitis C.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.Semantic proximity Read ↗

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.Semantic proximity Read ↗

The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C.Semantic proximity Read ↗

Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.Semantic proximity Read ↗

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.Semantic proximity Read ↗

The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.Semantic proximity Read ↗

Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.Semantic proximity Read ↗

PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection.Semantic proximity Read ↗

Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection.Semantic proximity Read ↗

Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C.Semantic proximity Read ↗

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