The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.

doi:10.1016/j.jhep.2010.02.034

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Article

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.

Journal of hepatology - 1 Aug 2010

Romeo Stefano, Sentinelli Federica, Cambuli Valentina M, Incani Michela, Congiu Tiziana, Matta Vanessa, Pilia Sabrina, Huang-Doran Isabel, Cossu Efisio, Loche Sandro, Baroni Marco G

Abstract excerpt

BACKGROUND & AIMS: Childhood obesity is a growing problem worldwide. Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults. In this study we add further insight into the role of PNPLA3 by exploring whether this association begins early in life...

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Identifiers

PMID: 20546964
DOI: 10.1016/j.jhep.2010.02.034

Genes

PNPLA3

Variants

rs738409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.PMID 20546964Read ↗

Effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta-analysis of paediatric and adolescent individuals.Semantic proximity Read ↗

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.Semantic proximity Read ↗

Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.Semantic proximity Read ↗

Influence of genetics on clinical trajectories in children with MASLD: role of the PNPLA3 I148M polymorphism.Semantic proximity Read ↗

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.Semantic proximity Read ↗

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.Semantic proximity Read ↗

The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.Semantic proximity Read ↗

Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.Semantic proximity Read ↗

Association of PNPLA3 I148M with Liver Disease Biomarkers in Latinos.Semantic proximity Read ↗

PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.Semantic proximity Read ↗

I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study.Semantic proximity Read ↗

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