Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.

doi:10.1002/hep.24123

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Article

Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.

Hepatology (Baltimore, Md.) - 1 Mar 2011

Valenti Luca, Rumi Mariagrazia, Galmozzi Enrico, Aghemo Alessio, Del Menico Benedetta, De Nicola Stella, Dongiovanni Paola, Maggioni Marco, Fracanzani Anna Ludovica, Rametta Raffaela, Colombo Massimo, Fargion Silvia

Abstract excerpt

UNLABELLED: Steatosis has been reported to negatively influence the natural history of chronic hepatitis C (CHC), but controversy remains over its causal role due to the confounding effect of adiposity, insulin resistance, and diabetes. The rs738409 C>G patatin-like phospholipase domain-containing 3 (PNPLA3) single nucleotide polymorphism (SNP), encoding for the I148M protein variant, influences liver fat without...

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PMID: 21319195
DOI: 10.1002/hep.24123

Genes

PNPLA3

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