Article
A custom correlation coefficient (CCC) approach for fast identification of multi-SNP association patterns in genome-wide SNPs data.
Genetic epidemiology - 1 Nov 2014
Climer Sharlee, Yang Wei, de las Fuentes Lisa, Dávila-Román Victor G, Gu C Charles
Abstract excerpt
Complex diseases are often associated with sets of multiple interacting genetic factors and possibly with unique sets of the genetic factors in different groups of individuals (genetic heterogeneity). We introduce a novel concept of custom correlation coefficient (CCC) between single nucleotide polymorphisms (SNPs) that address genetic heterogeneity by measuring subset correlations autonomously. It is used to...
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