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Article

Optimized phenotype definitions boost GWAS power.

PLoS computational biology - 1 Jul 2026

Zietz Michael, Brown Kathleen LaRow, Gisladottir Undina, Tatonetti Nicholas P

Abstract excerpt

Complex diseases are a major challenge, and genetics underlie a large fraction of the risk for these diseases. Observational data are helpful for this research due to large scale, cost-effectiveness, information on many different conditions, and future scalability, but they reflect factors such as healthcare processes, access to care, and broader societal effects like systemic biases. Here, we introduce MaxGCP, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42384672
DOI: 10.1371/journal.pcbi.1014431
PMCID: PMC13340767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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