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Article

A clustering linear combination method for multiple phenotype association studies based on GWAS summary statistics.

Scientific reports - 28 Feb 2023

Wang Meida, Cao Xuewei, Zhang Shuanglin, Sha Qiuying

Abstract excerpt

There is strong evidence showing that joint analysis of multiple phenotypes in genome-wide association studies (GWAS) can increase statistical power when detecting the association between genetic variants and human complex diseases. We previously developed the Clustering Linear Combination (CLC) method and a computationally efficient CLC (ceCLC) method to test the association between multiple phenotypes and a...

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PMID: 36854754
DOI: 10.1038/s41598-023-30415-3
PMCID: PMC9975197

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